[The effect of multichannel electrostimulation of neck nervous structures on the brain connectivity of patients with depressive disorders]. / Vliianie mnogokanal'noi élektrostimuliatsii nervnykh struktur shei na konnektivnost' golovnogo mozga u patsientov s depressivnym rasstroistvom.

AIM: To study neurophysiological processes during multichannel electrostimulation in patients with depressive disorder. MATERIAL AND METHODS: The study involved 6 patients with depressive disorder (F33). The technology noninvasive multichannel stimulation of neck neural struct SYMPATHOKOR-01 device. Clinical and psychometric methods, functional neuroimaging (fMRTP) and multichannel electroencephalography (EEG) were used to assess treatment effect. RESULTS: In all patients, fMRTP and EEG results show the disturbances of brain connectivity, which are correlated with the clinical state of the disease, before treatment. After five stimulation procedures, there is an increase in functional connection of the medial prefrontal cortex (according to rs-fMRI results) and an increase in the synchronization of various parts of the cortex (EEG results). CONCLUSION: The results demonstrate the possibilities of multichannel electrical stimulation of the neck nervous structures to restore the intracerebral connections disturbed during depression due to the activation of neuroplasticity.

[The possibilities of neurostimulation (sympathetic correction) in the treatment of amnestic (Korsakoff's) psychosis]. / Vozmozhnosti neirostimuliatsii (simpatokorrektsii) v terapii amnesticheskogo (korsakovskogo) psikhoza.

AIM: To evaluate the efficacy of non-invasive multichannel electrical stimulation (sympathetic correction) in patients with alcohol amnesic (Korsakoff's) psychosis. MATERIAL AND METHODS: Thirty-seven men, aged 33-48 years, with Korsakoff's (amnestic) psychosis were studied. The duration of disease varied from 12 to 24 month. The device of electrical stimulation of neck nerve structures was used for neuroelectrostimulation. Treatment included 15 sessions within 3 weeks. During this period, patients did not receive pharmacological therapy. The Frontal Assessment Battery (FAB), the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) were used to determine changes in cognitive state of patients. Electroencephalography with qEEG analysis and spectral analysis of heart rate variability (HRV) were carried out as well. RESULTS AND CONCLUSION: Positive effects of treatment were observed in all patients that suggested the high therapeutic potential of the neuroelectrostimulation method.

[A new method of treatment of Korsakoff's (amnestic) psychosis: neurostimulation-correction of the sympathetic nervous system]. / Novyi metod terapii korsakovskogo (amnesticheskogo) psikhoza: neirostimuliatsiia v vide simpatokorrektsii.

AIM: To provide a rationale for a new method of neurostimulation - correction of the sympathetic nervous system based on the evolution of the electrical stimulation of the brain as a component of neurorehabilitation. MATERIAL AND METHODS: Authors treated 16 patients with Korsakoff's (amnestic) psychosis using this method. RESULTS: Positive results were obtained in all patients. A typical case is described. CONCLUSION: The proposed method has a high therapeutic potential.

Multi-electrode neurostimulation system for treatment of cognitive impairments.

Peculiarities of neurostimulation organization by a multi-electrode system are considered. The system forms the spatially distributed field of current pulses that impact the nerve centers of the neck. An example is given for technical implementation of such a system in device SYMPATHOCOR and the method of its application: the dynamic correction of activity of the sympathetic nervous system. Results of its clinic application to treating the children with the attention deficit syndrome are given. It is shown that taking into account pathophysiological peculiarities of such a syndrome, it could be considered as a general model of cognitive impairments.

[The activity of peroxidation of lipids in biologic samples of patients with recurrent diseases of upper respiratory tracts].

The parameters of peroxidation of lipids in blood and saliva were analyzed on sampling of 60 patients with recurrent diseases of upper respiratory tracts during period of remission. It is established that the content of primary and secondary products of peroxidation of neutral lipids in blood plasma is lower as compared with healthy persons. The content of end products of peroxidation of neutral lipids and products of oxidation of phospholipids in blood plasma is higher as compared with healthy persons. The characteristics of alterations of intermediates of peroxidation of lipids in various biologic samples depend on the localization of inflammatory process.